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Hiroshi Shimizu Selected Research

Therapeutics

4/2024Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ.
4/2024Acute respiratory failure caused by brainstem demyelinating lesions in an older patient with an atypical relapsing autoimmune disorder.
1/2024Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis.
10/2023Clinical, imaging, and molecular features of radiation-induced glioblastomas developing more than 20 years after radiation therapy for intracranial germinomatous germ cell tumor: illustrative cases.
1/202213C metabolic flux analysis clarifies distinct metabolic phenotypes of cancer cell spheroid mimicking tumor hypoxia.
10/2021Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy.
1/2021Altered replication stress response due to CARD14 mutations promotes recombination-induced revertant mosaicism.
3/2020Diagnosis and management of pemphigus: Recommendations of an international panel of experts.
1/2019Efficient Gene Reframing Therapy for Recessive Dystrophic Epidermolysis Bullosa with CRISPR/Cas9.
12/2018Loss of TRIM29 Alters Keratin Distribution to Promote Cell Invasion in Squamous Cell Carcinoma.
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Hiroshi Shimizu Research Topics

Disease

54Bullous Pemphigoid (Pemphigoid)
12/2021 - 08/2003
26Neoplasms (Cancer)
01/2024 - 02/2004
15Blister (Bulla)
12/2021 - 04/2006
14Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa)
01/2019 - 02/2002
14Ichthyosis (Xeroderma)
01/2019 - 11/2003
11Autoimmune Diseases (Autoimmune Disease)
04/2024 - 03/2007
11Melanoma (Melanoma, Malignant)
11/2020 - 02/2004
11Pemphigus (Pemphigus Vulgaris)
03/2020 - 01/2002
11Atopic Dermatitis (Atopic Eczema)
03/2017 - 02/2005
10Lamellar Ichthyosis (Harlequin Ichthyosis)
07/2010 - 07/2005
9Epidermolysis Bullosa
01/2021 - 01/2006
8Inflammation (Inflammations)
01/2019 - 04/2004
8Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara)
12/2017 - 06/2002
6Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris)
07/2014 - 02/2007
6Epidermolytic Hyperkeratosis (Bullous Congenital Ichthyosiform Erythroderma)
05/2011 - 02/2002
5Pruritus (Itching)
03/2021 - 02/2005
5Starvation
01/2019 - 05/2007
5Erythema
11/2016 - 01/2003
5Psoriasis (Pustulosis Palmaris et Plantaris)
04/2016 - 09/2002
5Skin Diseases (Skin Disease)
05/2012 - 06/2002
4Lymphoma (Lymphomas)
01/2023 - 03/2016
4Sarcoma (Soft Tissue Sarcoma)
10/2021 - 11/2006
4Epidermolysis Bullosa Acquisita (Acquired Epidermolysis Bullosa)
12/2019 - 06/2003
4Stevens-Johnson Syndrome (Lyell's Syndrome)
11/2019 - 05/2003
4Hypersensitivity (Allergy)
06/2019 - 09/2006
4Mycosis Fungoides
03/2019 - 05/2006
4Asthma (Bronchial Asthma)
12/2018 - 11/2006
4Contact Dermatitis (Eczema, Contact)
03/2017 - 05/2003
4Muscular Dystrophies (Muscular Dystrophy)
04/2011 - 02/2005
4Chanarin-Dorfman Syndrome
10/2010 - 11/2003
4Wounds and Injuries (Trauma)
02/2008 - 01/2005
4Oculocutaneous Albinism (Albinism, Yellow Mutant)
07/2005 - 01/2002
3Type 2 Diabetes Mellitus (MODY)
03/2021 - 01/2009
3Vasculitis (Vasculitides)
04/2019 - 11/2015
3Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
11/2018 - 09/2013
3Linear IgA Bullous Dermatosis
12/2017 - 11/2010
3Neoplasm Metastasis (Metastasis)
08/2017 - 02/2004
3Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris)
09/2015 - 06/2007
3Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis)
09/2009 - 01/2004
2Transverse Myelitis (Necrotizing Myelitis)
04/2024 - 11/2015
2Respiratory Insufficiency (Respiratory Failure)
04/2024 - 10/2003
2Carcinogenesis
01/2024 - 08/2020
2Glioma (Gliomas)
01/2024 - 10/2023
2Aneurysm (Aneurysms)
12/2023 - 05/2009
2Hematoma
12/2023 - 12/2017
2Adenocarcinoma
06/2023 - 11/2006
2Carcinoma (Carcinomatosis)
06/2023 - 09/2017
2Macular Edema
05/2022 - 01/2013
2Myotonic Dystrophy (Dystrophia Myotonica)
01/2022 - 04/2016

Drug/Important Bio-Agent (IBA)

44AutoantibodiesIBA
04/2024 - 08/2003
28Collagen Type XVIIIBA
10/2020 - 03/2007
26Proteins (Proteins, Gene)FDA Link
01/2022 - 05/2003
22Immunoglobulin G (IgG)IBA
01/2022 - 08/2003
13AntibodiesIBA
04/2024 - 06/2003
11AntigensIBA
01/2022 - 08/2003
11EpitopesIBA
07/2020 - 12/2009
11Filaggrin ProteinsIBA
12/2018 - 02/2002
11LipidsIBA
11/2011 - 11/2003
10Macrophage Migration-Inhibitory FactorsIBA
04/2011 - 03/2002
9Collagen Type VIIIBA
05/2018 - 06/2003
8DNA (Deoxyribonucleic Acid)IBA
01/2024 - 12/2004
8EnzymesIBA
01/2022 - 05/2003
7AutoantigensIBA
01/2019 - 03/2007
7Keratins (Keratin)IBA
12/2018 - 02/2002
6Dipeptidyl-Peptidase IV InhibitorsIBA
03/2021 - 01/2017
6Peptides (Polypeptides)IBA
01/2019 - 02/2002
5Matrix Metalloproteinases (MMPs)IBA
12/2019 - 01/2016
5CollagenIBA
01/2019 - 03/2010
5NitrogenIBA
01/2019 - 12/2004
5PlectinIBA
12/2017 - 02/2005
5Glycine (Aminoacetic Acid)FDA LinkGeneric
07/2014 - 02/2002
4ImmunosorbentsIBA
01/2022 - 05/2003
4Immunoglobulin E (IgE)IBA
04/2015 - 02/2005
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2013 - 04/2004
4Nonsense Codon (Nonsense Mutation)IBA
07/2008 - 12/2003
3Intravenous Immunoglobulins (IVIG)FDA Link
01/2020 - 04/2009
3CytokinesIBA
01/2020 - 07/2006
3Codon (Codons)IBA
01/2019 - 12/2009
3Glucose (Dextrose)FDA LinkGeneric
01/2018 - 12/2016
3DapsoneFDA Link
01/2017 - 03/2006
3DesmogleinsIBA
11/2016 - 01/2002
3Amino AcidsFDA Link
09/2013 - 05/2007
3Keratin-5 (Keratin 5)IBA
09/2013 - 06/2002
3pigment epithelium-derived factorIBA
03/2010 - 04/2004
3SteroidsIBA
07/2009 - 04/2002
3Fas Ligand Protein (Fas Ligand)IBA
11/2008 - 05/2003
3Keratin-10IBA
07/2008 - 12/2004
3Indicators and Reagents (Reagents)IBA
10/2007 - 04/2004
3Monophenol Monooxygenase (Tyrosinase)IBA
09/2004 - 01/2002
2Bevacizumab (Avastin)FDA Link
10/2023 - 01/2013
2Adrenal Cortex Hormones (Corticosteroids)IBA
01/2022 - 07/2016

Therapy/Procedure

28Therapeutics
04/2024 - 10/2003
5Drug Therapy (Chemotherapy)
10/2023 - 01/2008
3Radiotherapy
10/2023 - 05/2013
3Hematopoietic Stem Cell Transplantation
03/2016 - 01/2008
3Bone Marrow Transplantation (Transplantation, Bone Marrow)
07/2015 - 07/2004
2Ligation
01/2024 - 05/2009
2Light Coagulation
06/2022 - 05/2022
2Aftercare (After-Treatment)
05/2022 - 01/2018
2Lasers (Laser)
05/2022 - 01/2022